無法確定具體原因，但可能是以下幾種情況之一：
1. 軟件故障：嘗試重新安裝或更新Excel軟件，以修復可能存在的軟件問題。
2. 文件損壞：如果該文件是在最近創建或修改的，那么它有可能損壞。嘗試使用“修復文件”功能來修復損壞的文件。
3. 病毒感染：運行殺毒軟件來掃描和清除任何潛在的病毒或惡意軟件。
4. 系統設置問題：確保系統設置中啟用了“自動恢復關閉”選項，并檢查是否啟用了“自動保存”功能。
如果以上方法都無法解決問題，請考慮聯系微軟技術支持人員或尋求專業幫助。

Windows Registry Editor Version 5.00

[HKEY_CLASSES_ROOTApplicationsEXCEL.EXE]

[HKEY_CLASSES_ROOTApplicationsEXCEL.EXEshell]
@="Open"

[HKEY_CLASSES_ROOTApplicationsEXCEL.EXEshellNew]
@="新建(&N)"

[HKEY_CLASSES_ROOTApplicationsEXCEL.EXEshellNewcommand]
@=""C:Program FilesMicrosoft OfficeOFFICE11EXCEL.EXE" /e /n"
"command"=hex(7):26,00,69,00,67,00,41,00,56,00,6e,00,2d,00,7d,00,66,00,28,00,
5a,00,58,00,66,00,65,00,41,00,52,00,36,00,2e,00,6a,00,69,00,45,00,58,00,43,
00,45,00,4c,00,46,00,69,00,6c,00,65,00,73,00,3e,00,21,00,44,00,65,00,40,00,
5d,00,56,00,7a,00,28,00,72,00,3d,00,66,00,60,00,31,00,6c,00,66,00,71,00,60,
00,3f,00,52,00,26,00,20,00,2f,00,65,00,20,00,2f,00,6e,00,00,00,00,00

[HKEY_CLASSES_ROOTApplicationsEXCEL.EXEshellNewddeexec]
@="[new("%1")]"

[HKEY_CLASSES_ROOTApplicationsEXCEL.EXEshellNewddeexecapplication]
@="Excel"

[HKEY_CLASSES_ROOTApplicationsEXCEL.EXEshellNewddeexec opic]
@="system"

[HKEY_CLASSES_ROOTApplicationsEXCEL.EXEshellOpen]
@="打開(&O)"

[HKEY_CLASSES_ROOTApplicationsEXCEL.EXEshellOpencommand]
@=""C:Program FilesMicrosoft OfficeOFFICE11EXCEL.EXE" /e"
"command"=hex(7):26,00,69,00,67,00,41,00,56,00,6e,00,2d,00,7d,00,66,00,28,00,
5a,00,58,00,66,00,65,00,41,00,52,00,36,00,2e,00,6a,00,69,00,45,00,58,00,43,
00,45,00,4c,00,46,00,69,00,6c,00,65,00,73,00,3e,00,21,00,44,00,65,00,40,00,
5d,00,56,00,7a,00,28,00,72,00,3d,00,66,00,60,00,31,00,6c,00,66,00,71,00,60,
00,3f,00,52,00,26,00,20,00,2f,00,65,00,00,00,00,00

[HKEY_CLASSES_ROOTApplicationsEXCEL.EXEshellOpenddeexec]
@="[open("%1")]"

[HKEY_CLASSES_ROOTApplicationsEXCEL.EXEshellOpenddeexecapplication]
@="Excel"

[HKEY_CLASSES_ROOTApplicationsEXCEL.EXEshellOpenddeexec opic]
@="system"

[HKEY_CLASSES_ROOTApplicationsEXCEL.EXEshellOpenAsReadOnly]
@="以只讀方式打開"
"Extended"=""

[HKEY_CLASSES_ROOTApplicationsEXCEL.EXEshellOpenAsReadOnlycommand]
@=""C:Program FilesMicrosoft OfficeOFFICE11EXCEL.EXE" /h /e"
"command"=hex(7):26,00,69,00,67,00,41,00,56,00,6e,00,2d,00,7d,00,66,00,28,00,
5a,00,58,00,66,00,65,00,41,00,52,00,36,00,2e,00,6a,00,69,00,45,00,58,00,43,
00,45,00,4c,00,46,00,69,00,6c,00,65,00,73,00,3e,00,21,00,44,00,65,00,40,00,
5d,00,56,00,7a,00,28,00,72,00,3d,00,66,00,60,00,31,00,6c,00,66,00,71,00,60,
00,3f,00,52,00,26,00,20,00,2f,00,68,00,20,00,2f,00,65,00,00,00,00,00

[HKEY_CLASSES_ROOTApplicationsEXCEL.EXEshellOpenAsReadOnlyddeexec]
@="[open("%1",,,,,,,,,,,,,,1,,1)]"

[HKEY_CLASSES_ROOTApplicationsEXCEL.EXEshellOpenAsReadOnlyddeexecapplication]
@="Excel"

[HKEY_CLASSES_ROOTApplicationsEXCEL.EXEshellOpenAsReadOnlyddeexec opic]
@="system"

[HKEY_CLASSES_ROOTApplicationsEXCEL.EXEshellPrint]
@="打印(&P)"

[HKEY_CLASSES_ROOTApplicationsEXCEL.EXEshellPrintcommand]
@=""C:Program FilesMicrosoft OfficeOFFICE11EXCEL.EXE" /e"
"command"=hex(7):26,00,69,00,67,00,41,00,56,00,6e,00,2d,00,7d,00,66,00,28,00,
5a,00,58,00,66,00,65,00,41,00,52,00,36,00,2e,00,6a,00,69,00,45,00,58,00,43,
00,45,00,4c,00,46,00,69,00,6c,00,65,00,73,00,3e,00,21,00,44,00,65,00,40,00,
5d,00,56,00,7a,00,28,00,72,00,3d,00,66,00,60,00,31,00,6c,00,66,00,71,00,60,
00,3f,00,52,00,26,00,20,00,2f,00,65,00,00,00,00,00

[HKEY_CLASSES_ROOTApplicationsEXCEL.EXEshellPrintddeexec]
@="[open("%1")][print()][close()]"

[HKEY_CLASSES_ROOTApplicationsEXCEL.EXEshellPrintddeexecapplication]
@="Excel"

[HKEY_CLASSES_ROOTApplicationsEXCEL.EXEshellPrintddeexecifexec]
@="[open("%1")][print()][quit()]"

[HKEY_CLASSES_ROOTApplicationsEXCEL.EXEshellPrintddeexec opic]
@="system"

[HKEY_CLASSES_ROOTApplicationsEXCEL.EXEshellPrintto]

[HKEY_CLASSES_ROOTApplicationsEXCEL.EXEshellPrinttocommand]
@=""C:Program FilesMicrosoft OfficeOFFICE11EXCEL.EXE" /e"
"command"=hex(7):26,00,69,00,67,00,41,00,56,00,6e,00,2d,00,7d,00,66,00,28,00,
5a,00,58,00,66,00,65,00,41,00,52,00,36,00,2e,00,6a,00,69,00,45,00,58,00,43,
00,45,00,4c,00,46,00,69,00,6c,00,65,00,73,00,3e,00,21,00,44,00,65,00,40,00,
5d,00,56,00,7a,00,28,00,72,00,3d,00,66,00,60,00,31,00,6c,00,66,00,71,00,60,
00,3f,00,52,00,26,00,20,00,2f,00,65,00,00,00,00,00

[HKEY_CLASSES_ROOTApplicationsEXCEL.EXEshellPrinttoddeexec]
@="[open("%1")][print(1,,,,,,,,,,,2,"%2")][close()]"

[HKEY_CLASSES_ROOTApplicationsEXCEL.EXEshellPrinttoddeexecapplication]
@="Excel"

[HKEY_CLASSES_ROOTApplicationsEXCEL.EXEshellPrinttoddeexecifexec]
@="[open("%1")][print(1,,,,,,,,,,,2,"%2")][quit()]"

[HKEY_CLASSES_ROOTApplicationsEXCEL.EXEshellPrinttoddeexec opic]
上面的紅字我暈
@="system"

右擊一個excel文檔--打開方式--選擇要打開它的程序如excel--勾選“始終使用選擇的程序打開這種文件”

我也遇到過這種問題.樓上說的方法不對.不是打開方式問題,也不是中毒.
先打開EXCEL,點工具”菜單再點“選項”對話框，在“常規”選項卡中，把“忽略其他應用程序”項前面的勾去掉就可以了.保證行.